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KMID : 0369919880030000083
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Journal of Pharmaceutical Sciences (C.B.N.)
1988 Volume.3 No. 0 p.83 ~ p.89
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Effects of Panax Ginseng on the Development of Morphine Tolerance and Dependence
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Kim, Hack-Seang/김학성
Shin, Sung-Hee/Choi, Kang-Ju/Kim, Suk-Chang/신성희/최강주/김석창
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Abstract
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Antagonisms of the analgesic effect of morphine in mice by ginsenoside Rbl, Rb21 Rgl and Re were investigated in these experiments. These ginsenosides antagonized the analgesic effect induced by morphine in mice and the administration of 2,4-dihydroxyphenylalanine or 5-hydroxytryptophan reduced the antagonisms of morphine analgesia by the ginsenosides. Possible mechanisms involved in the antagonistic actions of the ginsenosides on morphine analgesia were described.
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